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Borza, Dorin-Bogdan
One or more keywords matched the following properties of Borza, Dorin-Bogdan
PropertyValue
keywords Alport syndrome
overview My research leverages my multi-disciplinary training in biochemistry, immunology and nephrology to elucidate the molecular mechanisms underlying the etiology and pathogenesis of antibody-mediated glomerular diseases. I have extensive experience and expertise studying the structure, function and pathobiology of type IV collagen and its role in acquired and inherited diseases of the glomerular basement membrane (GBM). I rank among the leading experts in the areas of Goodpasture disease (anti-GBM antibody nephritis) and Alport syndrome. I am also interested in the pathomechanisms of and factors contributing to health disparities in lupus nephritis and membranous nephropathy.
One or more keywords matched the following items that are connected to Borza, Dorin-Bogdan
Item TypeName
Academic Article Alport alloantibodies but not Goodpasture autoantibodies induce murine glomerulonephritis: protection by quinary crosslinks locking cryptic a3(IV) collagen autoepitopes in vivo.
Academic Article Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis.
Academic Article Quaternary epitopes of a345(IV) collagen initiate Alport post-transplant anti-GBM nephritis.
Academic Article Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways.
Academic Article A human-mouse chimera of the alpha3alpha4alpha5(IV) collagen protomer rescues the renal phenotype in Col4a3-/- Alport mice.
Academic Article Distinct epitopes for anti-glomerular basement membrane alport alloantibodies and goodpasture autoantibodies within the noncollagenous domain of alpha3(IV) collagen: a janus-faced antigen.
Academic Article Loss of alpha3/alpha4(IV) collagen from the glomerular basement membrane induces a strain-dependent isoform switch to alpha5alpha6(IV) collagen associated with longer renal survival in Col4a3-/- Alport mice.
Academic Article The alloantigenic sites of alpha3alpha4alpha5(IV) collagen: pathogenic X-linked alport alloantibodies target two accessible conformational epitopes in the alpha5NC1 domain.
Academic Article Identification of noncollagenous sites encoding specific interactions and quaternary assembly of alpha 3 alpha 4 alpha 5(IV) collagen: implications for Alport gene therapy.
Academic Article Stem cell therapy for Alport syndrome: the hope beyond the hype.
Academic Article Cellular origins of type IV collagen networks in developing glomeruli.
Concept Nephritis, Hereditary
Grant Molecular pathogenesis of anti-glomerular basement membrane nephritis
Academic Article Type IV collagen of the glomerular basement membrane. Evidence that the chain specificity of network assembly is encoded by the noncollagenous NC1 domains.
Academic Article The NC1 domain of collagen IV encodes a novel network composed of the alpha 1, alpha 2, alpha 5, and alpha 6 chains in smooth muscle basement membranes.
Academic Article Choosing a mouse model to study the molecular pathobiology of Alport glomerulonephritis.
Academic Article A glycine substitution in the collagenous domain of Col4a3 in mice recapitulates late onset Alport syndrome.
Academic Article Editorial: Collagen IV nephropathies: Alport syndrome and beyond.
Search Criteria
  • Alport syndrome
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